Inflazome is working on drugs to target inflammasomes associated with Parkinson’s disease, Alzheimer’s disease, asthma, inflammatory bowel disease and arthritis, among other chronic inflammatory diseases. Activated NLRP3 acts as a ‘danger sensor’ in the body to release the pro-inflammatory cytokines IL-1β, IL-18 and induce uncontrolled, lytic cell death (pyroptosis). Roche veut racheter l’irlandais Inflazome, spécialisé dans le développement d’inhibiteurs de l’inflammasome NLRP3, afin de répondre aux besoins cliniques dans une grande variété de maladies inflammatoires (archives). }); Inflazome today revealed that it has closed a share purchase agreement with Swiss pharma giant Roche. Dublin and Cambridge, UK-based Inflazome is the second NLRP3-focused biotech Roche has acquired in less than two years, and although no numbers … Pharma: Roche se porte acquéreur de l’irlandais Inflazome. Matt Cooper, CEO of Inflazome, said the company was delighted to close this deal with Roche, which he called an outstanding pharmaceutical company with a broad commitment to multiple indications. This deal reinforces the importance of research collaboration and shows what can be achieved through commercialisation," the Professor added. Inflazome has developed a portfolio of oral, chemical-based NLRP3 blockers that are both "clinical and preclinical." With Inflazome now part of the Roche organization, Inflazome’s pioneering molecules are well positioned to be developed quickly and effectively so they can help patients suffering from debilitating diseases.”, Manus Rogan, Chairman and co-founding investor of Inflazome, said: “It has been a privilege to work alongside Matt, his team and my co-investors. We congratulate all the researchers involved for their tireless commitment to discovery and innovation and for making a real difference in society," he added. The treatment could be beneficial to people suffering from chronic, uncontrolled inflammation such as Parkinson’s Disease, asthma, arthritis, cardiovascular disease and chronic kidney disease. The acquisition gives Roche full rights to Inflazome’s entire portfolio which is composed of clinical and preclinical orally available small molecule NLRP3 inhibitors. US biotech Gilead Sciences clocked up the biggest deal of the yea so far in September, with its $21 billion…. $('#therapyAreaFilterContainerToggler').data('animation', ''); Irish biotech company Inflazome has been acquired by Swiss multinational healthcare company Roche for €380m - one of the largest deals in Irish biotech history. Under the terms of the deal, Inflazome's shareholders will receive an upfront payment of €380m. NEWS •⁠ POLITICS •⁠ BUSINESS •⁠ CULTURE, © Copyright 2020 In Queensland Media, InQueensland uses cookies. showHideToggle($('#therapyAreaFilterContainerToggler'), ''); The firm’s portfolio includes orally available small molecule NLRP3 inhibitors. Do you have confidence with the existing arrangements for the operation of the Protected Disclosures process or whistleblowing in the Irish health service? Inflazome was spun out of UQ’s commercialisation arm Uniquest and has been developing treatments for inflammatory diseases based on a research partnership between the two universities. Irish Medical Times is owned by MPI Media Limited, a member of the Metropolis Group; you can view our privacy and cookies policy here. Lazard acted as financial advisor and Goodwin Procter and Byrne Wallace acted as legal counsel to Inflazome. Inflammasomes are understood to drive many chronic inflammatory conditions, from Parkinson's and Alzheimer's to asthma, inflammatory bowel disease, chronic kidney disease, cardiovascular disease and arthritis. Several other privately held startups, among them NodThera, and Olatec Therapeutics, are developing NLRP3 inhibitors as well. L’activation de l’inflammasome NLRP3 dans le corps est impliquée dans de nombreuses maladies causées par une inflammation chronique incontrôlée. This website uses cookies to improve your experience. 30th September 2020, Acquisition deal gives Roche full rights to Inflazome’s portfolio. Inflazome is headquartered in Dublin, Ireland. Please review their details and accept them to load the content.Manage Preferences. Under the deal, Inflazome’s shareholders are eligible for additional milestone payments. In a statement on the Roche deal, Inflazome said its compounds would be developed for a "wide variety" of indications, but didn't provide specifics. A US biotechnology company, focused on cell therapy, that aspires to beat cancer via tumor-specific targeting. Please review their details and accept them to load the content. Swiss pharma company Roche is set to acquire Irish biotech firm Inflazome for an upfront payment of $449m (€380m). Swiss pharma company Roche is set to acquire Irish biotech firm Inflazome for an upfront payment of $449m (€380m). Inflazome announces acquisition by Roche Inflazome is a pioneering inflammasome company developing orally available NLRP3 inflammasome inhibitors to address clinical unmet needs across a wide variety of inflammatory diseases Acquisition of Inflazome gives Roche full rights to the Inflazome portfolio GALWAY, IRELAND--October 5, 2020--Written by Martin Lynch, European News Editor for Industrial Info (Galway, Ireland)--Swiss drug major Roche (Basel, Switzerland) has agreed to pay 380 million euro ($449 million) for Irish biotech company Inflazome (Dublin, Ireland) as it expands its portfolio of NLRP3 inhibitors for inflammatory diseases. Matt Cooper, Chief Executive Officer, Inflazome, commented: “We are delighted to close this deal with Roche, an outstanding pharmaceutical company with a broad commitment to multiple indications. $('#therapyAreaFilterContainerToggler').data('showText', 'Popular Filters'); By continuing to use our site you are agreeing to our, China 'ban' on imports sends coal prices plummeting, The bucks stop here - the businesses winning biggest from election cash splash, Sacking rumours: Bain pressured to come clean on fate of Virgin boss, Aurizon's $50m plan for emissions-free trains to haul Queensland coal to market. $(function(){ Pharma: Roche se porte acquéreur de l’irlandais Inflazome. Prof Cooper, who is Chief Executive Officer of Inflazome, commented: “With Inflazome now part of the Roche organisation, its pioneering molecules are well-positioned to be developed quickly and effectively so they can help patients suffering from debilitating diseases.”. A University of Queensland startup Inflazome has struck a €380 million ($A620 million) with pharmaceutical giant Roche. 21-09-2020. The company develops orally available drugs to address clinical needs in inflammatory diseases by targeting inflammasomes. The company is a leader in the development of inflammasome inhibitors. $('#therapyAreaFilterContainerToggler').data('startHidden', '1'); We need your consent to load this rte-player contentWe use rte-player to manage extra content that can set cookies on your device and collect data about your activity. RTÉ.ie is the website of Raidió Teilifís Éireann, Ireland's National Public Service Media. In addition to the upfront payment, Inflazome is also eligible to receive additional contingent payments, based on the achievement of predetermined milestones. Inflazome has raised €55m in Venture Capital financing from leading investors Forbion, Longitude Capital, Fountain Healthcare Partners and Novartis Venture Fund. The acquisition gives Roche full rights to Inflazome’s entire portfolio which is composed of clinical and preclinical orally available small molecule NLRP3 inhibitors. View source version on businesswire.com: https://www.businesswire.com/news/home/20200920005066/en/, Healthineers launches rapid coronavirus antigen test, sees tight supply, Countries turn to rapid antigen tests to contain second wave of COVID-19, https://www.businesswire.com/news/home/20200920005066/en/. Please read our privacy policy for more details.

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